Sentence examples for principle of targeting from inspiring English sources

He said he agreed with the principle of "targeting all members of Daesh … [but] of course we will need to see how the law and the drafting works".

The possibility in principle of targeting a GTPase GEF interface has been demonstrated for Rac1 Tiam1 [ 36, 37] and for RhoA LARG [ 38].

FXR is a nuclear hormone receptor which heterodimerises with RXR and thus this supports the principle of targeting nuclear hormone receptors in the development of novel anthelmintics.

In this commentary, the authors discuss the rationale, based on the physiologic principle of targeting both vital organs, of applying high-frequency oscillation and tracheal gas insufflation in acute respiratory distress syndrome patients with traumatic brain injury.

Whilst the principle of targeting funding at areas of greatest need is not questioned here, it should be recognised that these areas also have access to funding sources to address the wider determinants of health that are not available to more affluent communities.

Some candidate compounds that are active against persisters have been identified and, if they pass the safety and efficacy phase, are expected to be used together with current antibiotics or drugs for improved treatment based on the common principle of targeting both growing bacteria or cells and non-growing persisters.

We demonstrate that caveolin-1 negatively regulates vascular smooth muscle cell polyamine uptake and show that caveolin-1-regulated polyamine uptake is critical for proliferative advantage of caveolin-1 deficient cells, providing proof-of-principle for targeting this mechanism as a strategy to fight unwanted proliferation.

Importantly, COXibs were found to reduce the incidence of both familial and sporadic disease, providing important proof-of-principle for targeting COX/PG signaling [ 66- 69].

Studies with Nutlins provided in vitro and in vivo proof-of-principle for targeting p53 MDM2 interaction for cancer therapy.

We provide proof-of-principle for targeting Cav-1-regulated polyamine uptake as a strategy to fight unwanted VSMC proliferation as observed in restenosis.

Now we have the worst of all worlds: prescriptive guidelines from a government that has rubbished the principle of targets from the centre.