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The HaloPlex technology is a selective circularization-based method which is a further development of the principle of selector probes [ 11– 13].
Enrichment by DNA fragment circularization is based upon the principle of selector probes [ 6, 25] and gap-fill padlock or MIPs [ 26].
In addition to these, the HaloPlex technology from Agilent (solution-based) is a well-known example of an enrichment system featuring a selective circularization-based method that is a further development of the principle of selector probes used in several diagnostic approaches [ 42, 43].
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