Sentence examples for principle of equipoise from inspiring English sources

We have previously argued that trials operate on the borderline of success and failure due to the principle of equipoise [11],which implies that discovery remains possible only if RCTs are performed when there is substantial uncertainty with respect to the relative merits of interventions to be tested.

The principle of equipoise becomes the paradox of equipoise.

Therefore, the principle of equipoise is guaranteed in this clinical trial.

The pseudo-ethical principle of equipoise, with its inappropriate decision point, must be abandoned.

Figure  2 outlines the design of the MIOH-DS trial which follows the principle of equipoise.

However, a large majority of industry-sponsored trials must violate the principle of equipoise.

However, without first analysing the safety of this diagnostic strategy through an observational cohort design, the principle of clinical equipoise may not have justified a randomised study design.

Although the STICH has rightfully dampened the enthusiasm of neurosurgeons for performing surgery, it must be remembered that the trial was based on the principle of clinical equipoise and patients who the local investigator felt would most likely benefit from emergency surgery were not enrolled into the study.

The first major step to overcome in the facilitation of trials in trauma surgery is to encourage and enable surgeons to divorce themselves of their personal beliefs, and instead employ the principle of clinical equipoise, and focus on the wider 'public health' agenda.

Therefore, to include a patient in a randomized controlled trial, in addition to the principles of clinical equipoise (from the scientific community) and physician equipoise, it should be confirmed that the patient does not prefer any of the treatments being evaluated (i.e., there should be " patient equipoise" ).

However, the use of committees introduces the possibility of bias, either through post hoc amendments to study design 11 or by terminating studies that show the drug to be ineffective at a preliminary stage, violating the uncertainty principle and equipoise of treatment efficacy.