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The principle of cell filtration (such as ISET) [5] for isolating CTCs relies on the assumption that CTCs are larger than white blood cells (WBCs).
We propose a multi-compartment model of hematopoiesis, designed on the principle of cell flow conservation under stationary conditions.
I believe understanding such common constraints will reveal the basic design principle of cell architecture.
Another area of future development concerns copying the supramolecular principle of cell envelopes of archaea.
This biomimetic approach, copying the supramolecular principle of cell envelopes of Archaea or envelopes of a great variety of viruses, allows stabilizing functional lipid membranes at the macroscopic scale.
Because MDS42 was synthetically constructed and is therefore not a product of evolution in the wild nature, the antagonistic epistatic relationship between the genomic and environmental contributions suggested a universal innate principle of cell biology.
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It has been proposed that TNTs represent a novel and general biological principle of cell-to-cell communication and it becomes increasingly apparent that they fulfill important functions in the physiological processes of multicellular organisms.
In 2004, a new principle of cell-to-cell communication between animal cells, based on the formation of thin membrane channels, was reported (Rustom et al. 2004).
In these studies, Caspersson united principles of cell biology and biochemistry with techniques such as spectroscopy and ultraviolet microscopy.
These findings illustrate principles of cell circuit design and provide a quantitative perspective on cell interactions.
A fundamental underlying problem is a failure to incorporate principles of cell and molecular biology into an integrated evolution-focused biology curriculum.
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