In conclusion, development of biomarkers assessing the turnover of minor collagens may provide novel and translational diagnostic tools for investigating the effect of known drug targets on cartilage in preclinical or clinical settings, thereby providing proof of principle for test of those drugs in OA clinical trials.
These models recapitulate specific molecular pathways in tumor initiation or progression and provide a biological system in which to study the disease process for assessing efficacy of new therapies and proof-of-principle for testing molecularly targeted drugs.
In Cameroon, despite the fact that the majority of doctors and parents of SCD children and adult SCD patients agreed with the principle of testing for prenatal genetic diagnosis of SCD (78.7%, 89.8% and 89.2%, respectively), parents (62.5% acceptance) were more in favor of termination of an SCD-affected pregnancy than doctors and adult patients (36.1% and 40.9% acceptance, respectively) [ 6].
In conclusion, we believe that the findings of this study provide the proof of principle for further testing of dose intense regimens in adult LCH, as treatment intensity and quality of initial response rather than treatment duration or maintenance therapy emerged as important determinants of the final outcome.
The same principle is applied for testing other chemicals developed for their toxic properties, such as pesticides.
It is possible to find a definition in the report entitled General Principles for Fatigue Testing of Metals, which was published in 1964 by The International Organization for Standardization in Switzerland.
The International Stem Cell Banking Initiative ISCBII) has been created by the International Stem Cell Forum, a group of national and international stem cell research funding bodies, to develop a set of best practices and principles for banking, testing, and distributing hESCs for therapy [ 74].
Such QI principles are important for testing effectiveness, for theory building and for developing sorely needed adaptations of QI interventions in a local context.
In principle, for a screening test to be considered worthwhile, the factors included in any risk-factor model need to be strongly associated with the disease(s) of concern, with some variation in exposure to these within the population (Wald et al, 1999).
However, the WHO and ICH guidelines provide only study design advice and general principles for tumorigenicity tests.
We utilised this principle to test for the possibility that a high level of IAP contributes to apoptosis resistance in RCC.
