2. Adopt individualized criteria to choose adequate drugs for every clinical condition according to the RUM principles (efficacy, safety, convenience and cost).
In principle, the efficacy of drug therapy can be followed by monitoring the decline in fragment abundance.
A clinical development model has suggested that cancer vaccines be investigated in 2 categories of clinical trials: proof-of- principle and efficacy.
A lot of experimental work is needed on the path to an imaging biomarker development and acceptance, proving the concept, the mechanism, the principle, the efficacy and effectiveness up to its use as surrogate end-point in clinical studies [42].
Various combinatorial shRNA-expression systems have been shown to delay effectively the emergence of shRNA-resistant HIV-1 in cell culture [15], [36], proving in principle the efficacy of a multiple targeting RNAi strategy against a rapidly evolving target.
In principle, the efficacy of the treatment may be different for various subgroups (e.g., inpatients compared with outpatients).
The Pharmaceuticals and Medical Devices Agency PMDAA) of Japan works on the principle that efficacy and safety must be adequately evaluated until approval is granted (Our philosophy. Reviews and related services).
In accordance with the intention-to-treat (ITT) principle, the efficacy analysis set was defined as ITT population, including all randomized patients.
Different active and passive vaccines, including carbohydrate-based vaccines to aberrant glycostructures, are under clinical trials but have had limited success at proof of principle and efficacy stages [ 33].
