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O2 carrying capacity and saturation of the blood flow are the principle determinants of tissue O2 delivery.
It appears that increased cell size and matrix are the principle determinants for the cortical enlargement, whereas hippocampal enlargement was dependent on both increased proliferation and increased cell size and matrix.
MCP-1 is one of the most prevalent cytokines in tumour microenvironment and has been suggested to be one of the principle determinants of human tumour macrophage content [ 59], mediating monocyte/macrophage infiltration and thereby promoting tumour progression [ 60].
In our previous study in ALSPAC, we found that 2 of the principle determinants of BMI, namely total body lean mass and fat mass, are both strongly related to overall bone size and hence bone mass (21).
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Experimental observation has led to the commonly held view that native state protein topology is the principle determinant of mechanical strength.
The nature of the glacially controlled groundwater flow system rather than the magnitude of longitudinal forces generated by the glacier is the principle determinant of large-scale push moraine characteristics.
The prototype for this family, BPTI, contains two recognition loops, the first of which contains a single aa (Lys15) that is the principle determinant of inhibitor specificity.
Plants are at the trophic base of terrestrial ecosystems, and the diversity of plant species in an ecosystem is a principle determinant of community structure.
Their results, as well as others (31, 32), emphasize that the body distribution of fat, rather than cumulative fat mass as denoted by BMI, is a principle determinant of inflammation.
And finally, that total energy intake and fruit and vegetable consumption are the principle dietary determinants of geographical variations in mortality.
The principle neutralizing determinant of HIV-1 virus was mapped to the third variable (V3) loop region (residues 301 341) of gp120 [ 66- 68].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com