While important and demonstrating that downstream aberration of the RB pathway can bypass the response to endocrine therapy, loss of RB or cyclin D1 amplification does not represent the principle basis for acquired resistance in preclinical models.
Indeed, there is no evidence arising from the WF toxicity studies conducted to date that would bring into question the adequacy, reliability, and sufficiency of compositional and/or agronomic assessment as the principle basis for risk assessment of new GM crops.
Under this specification, optimum behaviour emerges in agents that conform to a free-energy principle, which provides a principled basis for understanding both action and perception [9], [10].
So how do you create a collaborative culture? 1. Know Thyself Whether you are an executive, a team lead, or an individual contributor, understanding who you are and what drives you to be your best is a principle foundation for any basis of leadership.
The principle and basis for analysis of the heat losses are introduced and the total heat loss of each apparatus are calculated or estimated, which agree well with the test result.
Computer science has revolutionized work at many engineering firms, but Balmond feels that design software is often used lazily or for mere effect, whereas he hopes that the A.G.U., which he calls "an investigation into a new aesthetic," can make rational principles the basis for generating designs.
The principle of majority rule, the basis for this apparent inconsistency, was considered irrelevant by the Southern Rhodesians.
In cases of this sort, the court must make a special effort to show that it is acting on the basis of legal principle, the only basis for a court to act.
Since our mental lives evidently depend on our existence as physical organisms, especially on the functioning of our central nervous systems, it seems natural to think that the physical sciences can in principle provide the basis for an explanation of the mental aspects of reality as well — that physics can aspire finally to be a theory of everything.
He has suggested a "Christian anthropic principle" as the basis for an ultimate understanding of the universe that combines scientific and religious perspectives (Ellis 1993).
This variational principle provides the basis for a numerical scheme which uses a cubic polynomial shape function to represent the shape of a grain-boundary.
