Following receptor activation (tyrosine kinase or GPCR) the class 1 PI 3-kinases phosphorylate the hydroxyl on the 3′ position of the inositol ring in PtdIns (phosphatidylinositol) lipids principally generating the second messenger PI 3,4,5 P3.
Mr. Portwood and Mr. Elliott worked principally on the first two Carmen games, "Where in the World Is Carmen Sandiego?" and "Where in the U.S.A.
Lord Brown, in the next paragraph, said he was inclined to base his conclusion "principally on the fifth of Lord Phillips's reasons".
He found the judicial instrument for the protection of private enterprise principally in the Fourteenth Amendment (1868), which had been passed as a civil rights measure.
The practice dates principally from the first orchestration (by the Russian composer Aleksandr Glazunov, 1894) of an arbitrary suite of piano music by Frédéric Chopin to which Fokine created Chopiniana (1908)—a title retained by Soviet ballet companies for what Diaghilev renamed Les Sylphides (1909).
The period of the kingdom can be divided into two epochs based on the legends, handed down to us principally in the first book of Livy's Ab Urbe condita ("From the City Having Been Founded", or simply "History of Rome").
These deaths occurred principally in the first six months (96.3%) and presented a significant linear decrease that was inversely proportional to the duration of treatment.
Since the C-terminal sixth ankyrin repeat of IκBα was dispensable for binding (Figure 1d), our analysis supports that TCL1A principally contacts the first N-terminal ankyrin repeats of IκBα.
This 6-week cycle was repeated principally during the first year after surgery.
The increase in the amount of enzyme increases the percentage of edema formed, principally in the first 24 h.
The extent of dissection will principally follow the third edition of the Gastric Cancer Treatment Guideline published by the Japanese Gastric Cancer Association [ 6].
