The non-aqueous nanoemulsion (NANE) useful for drug delivery and principally overcomes the problem of slow and incomplete dissolution of poorly water-soluble drugs with water unstable and/or unsavory drug [3, 4, 5, 6].
General disadvantages of the case-control design principally relate to the problem of recall bias, where individuals with the disease of interest tend to overestimate relevant past exposures [ 92, 93].
The British National Space Centre was established principally to work on the problem.
SMRs aim to capture the advantages of nuclear power – always-on, low-carbon energy – while avoiding the problems, principally the vast cost and time taken to build huge plants.
The 2013 review of RPA [commissioned by Defra] identified a number of mistakes made during the last CAP implementation period which have principally led to the problems RPA is still trying to remedy.
"Nothing burns so readily as a fireproof building" it said, quoting a common phrase, and the journal principally blamed the architects for the problem.
Credit for solving the problem belongs principally to John Augustus Roebling, a German-born American engineer who added a web truss to either side of his roadways and produced a structure so rigid that he successfully bridged the Niagara Gorge at Niagara Falls, New York, the Ohio River at Cincinnati, and, finally, in his masterpiece, the East River between Brooklyn and Manhattan at New York City.
For Fernández, while climate change poses a serious threat to the city's water supplies, she believes the issue is principally political: "The root of the problem lies in the commodification of the nation's water under [Pinochet's] dictatorship," she said.
The problem occurs principally because of the variation of properties spatially (Dawe 2004; Wheatcraft and Meerschaert 2008).
Then, the cell must be allowed to reproduce in a chaotic fashion, meaning the problem must principally affect the genes responsible for cell duplication, or those regulating it.
