Their chemical structures are principally able to interact with estrogen and androgen receptors as either agonists or antagonists.
It is the side chain that is principally used to interact with ligands, substrates and other residues [44], making knowledge of its position the crucial feature.
This comprises the non-covalently-associated extracellular α-DG, that interacts with laminin in the BM, and the transmembrane β-DG, that interacts principally with dystrophin to connect to the actin cytoskeleton.
VEGF-A interacts principally with VEGFR1 and VEGFR2.
EVER2 interacted principally with the N-terminal domain of TRADD, which contains the TRAF2 binding site (d1).
For instance, apocynin interacted principally with Pro, Glu, Asp, Arg and Arg, but only some of these residues are involved in the interaction with p22 phox.
The authors have observed that the improvements in compressive strength came principally from the fibers interacting with the advancing cracks.
Structural models suggest that these leaving groups interact during acylation principally with Tyr 150, Lys 315, and Thr 316 of the β-lactamase active site.
Similarly, LSTc interacts with NY18 principally through Neu5Ac, (H4, H5, H7, and H9), whereas signals belonging to Gal-2 and Glc appear to be absent or, at best, weaker than those found in the STD spectrum of the LSTc SC18 complex.
We supposed that SOCS3-KIR mutant interacted with PYK2 principally by the central SH2 domain, generating the inhibition effects, however the binding was a functional interaction, unstable and readily reversible, and the effects would be transient without the help of KIR domain, thus could not be detected by immunoprecipitation in vitro.
