Thus, the use of such mutants in combination with CD40 targeting principally allows further reduction of potential TRAIL-related side effects in cases where the latter and the apoptotic effect in the targeted tumor make differential use of TRAILR1 and TRAILR2.
The theoretical roots of organic agriculture go back a bit further, principally to the work of a British scientist by the name of Sir Albert Howard.
Principally, we could further consider this and other possible relations of signature hubs to reveal the consistency of signature hub lists.
Such bidirectional promoters could principally be located further away than 40 bp: however, we choose 40 nt cutoff since CAGE tags have a characteristic length of 20 21 bp and thus the tags under analysis are guaranteed to cover the entire region between the TSS on both strands.
They make up the prakriti but are further important principally as physiopsychological factors.
President Clinton's endorsement of Mr. Kohler was depicted in Washington as a reluctant move principally intended to avoid further strains with Germany.
Some facets of this methodological approach still require further consideration, principally an enhanced integration of climatology, geography and ecology into models considering evolution of the environment, some aspects of the interface between the geosphere and biosphere, and an accurate quantification of environmental change processes and rates.
The Washington Post articles, principally written by Barton Gellman, further characterized Cheney as having the strongest influence within the administration in shaping budget and tax policy in a manner that assures "conservative orthodoxy".
Neubauer arranged further equity financing, principally with Chemical Bank, Met Life, J.P. Morgan and Goldman , Sachs
However, this promising survival may also be linked to the fact that 47.5% of the patients went on to receive further active chemotherapy (principally of cisplatinum/5-FU).
