According to this view, angiogenic factors produced by the tumour may principally function to induce the initial stages of endothelial cell activation and migration into the stroma, and to provide a chemotactic stimulus for the subsequent directed migration of the resultant sprouting cells toward the tumour.
Although ELK3 principally functions as a repressor, Ras activation leads to a phosphorylated form of ELK3 that is highly active [ 33].
Ferritin (diameter of 13 nm; Fe core diameter of 7 nm), a protein found in most organisms and obtained from MP Biomedicals, functions principally to sequester excess Fe from cells.
Straight and convex edges experienced different use-lives and use-trajectories: both straight and convex edges were principally served for cutting/sawing and whittling, while some edges changed their functions to scraping as edge resharpening blunted the edges.
The mouse testis is composed of two main cell types with principally different origin and functions, the germ cells that differentiate from spermatogonia to mature spermatozoa and the somatic cells that carry out all supportive functions to make the spermatogenesis and reproduction possible.
In partial agreement with the tradition according to which PC is not the cornerstone or basic principle of logic, Łukasiewicz claims that its status is less secure than some other logical propositions, and that its function is principally to serve as a pragmatic norm.
Because, according to our analysis, inner membrane proteins with high aggregation propensities also contain many TS, they must be totally inserted in the membrane, limiting their actions to functions principally related to transport and respiratory activities.
Foxj1 is thought to function principally as a transcriptional activator (Lim et al., 1997).
Since its binding affinity for IGF-1 is higher than that for insulin, the receptor is thought to function principally as an IGF-1 receptor, but its biologic significance remains mostly unidentified.
These studies have revealed that Gli1 is dispensable and functions exclusively as an activator to reinforce or amplify the response to Hh activity that is mediated by Gli2, which functions principally as an activator and Gli3, which functions principally as a repressor (Pan et al., 2006; Tyurina et al., 2005; Wang et al., 2000).
