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According to this view, angiogenic factors produced by the tumour may principally function to induce the initial stages of endothelial cell activation and migration into the stroma, and to provide a chemotactic stimulus for the subsequent directed migration of the resultant sprouting cells toward the tumour.
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In this review we propose that the cerebellum principally functions to reduce variability, through the detection of stimulus onsets and the sub-division of longer durations, thus contributing to both sub-second and supra-second timing.
Although ELK3 principally functions as a repressor, Ras activation leads to a phosphorylated form of ELK3 that is highly active [ 33].
Because, according to our analysis, inner membrane proteins with high aggregation propensities also contain many TS, they must be totally inserted in the membrane, limiting their actions to functions principally related to transport and respiratory activities.
This used to be the principal function of Wall Street firms other than those principally in retail brokerage.
These VSMCs are highly differentiated cells that possess the contractile phenotype by expressing large amounts of contractile proteins, and function principally to maintain vascular tone.
Straight and convex edges experienced different use-lives and use-trajectories: both straight and convex edges were principally served for cutting/sawing and whittling, while some edges changed their functions to scraping as edge resharpening blunted the edges.
Progestins exert their biological functions principally by binding to PR [ 28].
Ferritin (diameter of 13 nm; Fe core diameter of 7 nm), a protein found in most organisms and obtained from MP Biomedicals, functions principally to sequester excess Fe from cells.
The mouse testis is composed of two main cell types with principally different origin and functions, the germ cells that differentiate from spermatogonia to mature spermatozoa and the somatic cells that carry out all supportive functions to make the spermatogenesis and reproduction possible.
For Hb, the rate of GHb synthesis is principally a function of the glucose concentration to which the erythrocytes are exposed, integrated over the time of exposure.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com