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These enzymes also have distinct tissue expression profiles: NAT2 is principally expressed in human liver and intestine, while NAT1 is expressed more ubiquitously [ 36].
We cannot exclude the possibility of ectopic expression below the level of detection of this technique, but our data strongly suggest that the variation in expression of these genes, which are principally expressed in the labyrinth zone, is not due to a gross enlargement or reduction of the labyrinth zone with respect to the other layers.
In the genotyping experiments, comparisons between peak areas generated from heterozygous individuals from gDNA and cDNA enabled us to obtain information about the principally expressed allele and the relative level of its expression.
His moderately liberal theology was principally expressed in his Philosophie und Religion (1885), in which he integrated aspects of Kantian Idealism with systematic theology.
These results show that fascin-1 is principally expressed in neural and mesenchymal derivatives during embryonic development.
One KLK of interest, KLK4, is principally expressed in basal and secretory cells of the prostate gland and is commonly overexpressed in malignant prostate tumours [7], [8].
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A parallel phenomenon showed that embryonic primary sensory neurons (Rohon-Beard cells), principally expressing AChE in embryos, survived the physiological apoptosis.
As our HEK293 cells principally express PDE4D5, PDE4D3 and PDE4B2 (Willoughby et al, 2007), and only the long isoforms of PDE4 (PDE4D3 and PDE4D5) are activated by PKA phosphorylation (MacKenzie et al, 2002), immunoreactivities from pull-down experiments were examined with a PDE4D-specific antibody.
However, taking into account that ERs, principally ERβ, are mainly expressed in male reproductive system (eg, testis, spermatozoa, and prostate), it is worth considering whether some, or even all, of the above-reported endocrine effects of BPA are due not to their androgenicity but rather to their abilities to interfere with the action of estrogen receptors.
The concentration of cyclodextrin encapsulated compounds from F. verna extracts (principally flavonoids expressed as quercetin) was evaluated by using the same spectrophotometric method.
A similar situation may occur in the case of FGF8, which is expressed principally in epithelial cells with very little expression seen in stromal tissues in this study and in other reports (Tanaka et al, 1998; Marsh et al, 1999).
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