Principally, these factors stabilize the damaged tissue during initial stages of tissue repair, and direct the local mesenchymal and epithelial cells to migrate, divide, and increase collagen and matrix synthesis, ultimately leading to fibrous connective tissue and scar formation [ 20].
At Macinaggio and Bastia, the coast is principally rock, and the meadow grows on a sandy plain that is damaged by trawling [ 34].
The restoration consisted principally of shoring up the structure and then mending a collapsed roof part, a tympanum, which left a large gaping hole in the main nave and damaged a sculptured pulpit and large stone candlestick used for the Paschal candle.
Principally an armored offensive, between 250 and 400 British tanks were put out of action, although recent examination suggests that only 140 were completely destroyed with an additional 174 damaged.
Kuznetsova, the winner of the US Open in 2004 and the runner-up to Henin here two years ago, could find little to damage her fellow Russian, principally because she could not keep the ball in court for long enough.
Severe and highly specific amnesic symptoms principally stem from damage to such brain structures as the mammillary bodies, circumscribed parts of the thalamus, and of the temporal lobe (e.g., the hippocampus).
In tumor cells that frequently have nonfunctional p53, DNA- or microtubules-damage principally leads to cell cycle arrest in the M phase due to prevention of the activation of the master mitotic kinase Cdk1/Cdc2 [48], [48].
Cellular injury caused by proteasome inhibition differs from both etoposide and linsidomine injury in that it does not principally involve DNA damage.
Also microglia is suggested to be an important player in complex response of nervous tissue to the chronic damage, principally by the activation of cascade of the immune response.
This site was selected because the target consists principally of fly muscle, with minimal risk of damaging any internal structures/organs.
