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Of these, IL-1β is the principally circulating isoform.
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Also, some PCBs or their metabolites may alter the activities (activation or inactivation) of specific T3- or T4-directed hepatic UDP-GT enzymes, affecting principally the circulating levels of T3 (Vansell and Klaassen 2002).
Many of these interferon responsive genes are present at increased levels in the activated versus resting lymphocytes observed here, suggesting that NK cells, T helper cells, and monocytes are the circulating cells principally responsive to type I interferon.
Insulin absorption is derived principally through the measure of circulating insulin concentration in relation to time since subcutaneous injection.
After menopause, ovarian estrogen biosynthesis is minimal, with circulating estrogens being derived principally from peripheral aromatization of adrenal androgens.
Third, circulating mediators of apoptosis are principally accessible for extracorporeal blood purification.
The carbon dioxide that is dissolved by the naturally circulating water appears in chemical analysis principally as carbonate ions.
Adiposity is thought to affect the risk of fibroids in postmenopausal women because peripheral tissues, principally body fat, become the major source of circulating oestrogens (when women are not taking HT) [ 36].
26 AIs inhibit the production of estrogen from androgens by aromatase in peripheral tissues (principally subcutaneous adipose tissue in postmenopausal women) and thereby decrease circulating estrogen levels.
These physiological abnormalities are principally the result of a considerable increase in tissue and circulating levels, and direct actions of Ang-II [ 24].
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