Sentence examples for principally by blocking from inspiring English sources
Several lines of evidence indicate that shits1 effects are not operating principally by blocking pacemaker neural output.
The TKIs utilised in this study are proposed to target tumour angiogenesis principally by blocking the pro-angiogenic signalling of VEGF and PDGF, growth factors that promote the growth and survival of new tumour vessels.
Sibutramine acts principally by blocking synaptic reuptake of serotonin and noradrenaline; 96 meta-analysis of results from eight controlled clinical trials of sibutramine in patients with T2DM indicated that decreases in body weight and waist circumference were significantly greater with this agent versus placebo, but sibutramine had minimal effects on glycemic control or lipids.
GABAB receptors in the apical dendrites of L5 pyramidal neurons are known to directly downregulate the active properties of dendrites, principally by blocking the underlying calcium conductances and activating G-protein coupled inwardly rectifying potassium channels (GIRK; for a review see Bettler et al., 2004).
Imatinib mesylate did not prevent the myofibroblast differentiation in vitro but inhibited fibroblast proliferation and migration and appeared to principally act by blocking pericyte recruitment [ 40].
By blocking Google, Facebook has blocked ME.
By blocking with one of your pieces.
Other than the heat retention properties of urban areas, the nighttime maximum in urban canyons could also be due to the blocking of "sky view" during cooling: surfaces lose heat at night principally by radiation to the comparatively cool sky, and this is blocked by the buildings in an urban area.
It also condemns members of the Security Council, including Britain but principally the United States, for blocking calls for rapid intervention.
This effect is mediated principally by the classical pathway of coagulation activation, through the formation of thrombin and fibrin, as inflammation was effectively blocked by administration of the thrombin inhibitor hirudin and an inhibitor of FVIIa.
If Erk signalling is blocked, LIF can largely be replaced by partial inhibition of glycogen synthase kinase-3, which acts principally by stabilizing intracellular β-catenin.
