The MTs principally bind metals from groups 1B and 2B of the Periodic Table of Elements (e.g., cadmium, copper, mercury, silver, zinc; [ 34, 35]), and in so doing form two metal-binding domains.
This theory has thus far been supported by several in vitro studies showing that parasite surface receptor kinases of the insulin-, the EGF- and the TGF-β-families can principally bind respective host-derived hormones [ 10, 11, 13, 37- 41].
Specifically, CsA and FK506 bind to intracellular proteins, principally cyclophilin A and FKBP12, respectively, and thereby inhibit the phosphatase calcineurin (Cn).
The results showed that OTX2 principally binds with the responsive element in Intron 1 of the p63 gene (Fig. 2B, upper panel).
During sequential extraction, Cu and Pb were principally distributed in the S/S ashes' organic matter fraction in the chelating agent, suggesting that metals bind to the chelating agent.
The radiotracers principally used are 2-deoxy-2-[18F] 2-deoxy-2-[18F] 2-deoxy-2-[18F] 2-deoxy-2-[18F]ter (H 2 15 O) [6], or radioactively labeled ligands that bind to specific receptors [7, 8].
Although phosphorus (P) is essential for plant growth, it is one of the least available nutrients in many agroecosystems, principally because P is bound to soil chemical and biological components that make it unavailable to growing plants (Richardson et al. 2009).
Using the yeast two-hybrid system it was further shown that the ligand binding domains (LBD) of the flatworm insulin receptor tyrosine kinases are principally able to bind human insulin [ 10, 11, 13], although it is not yet clear whether they are also activated by insulin when expressed at the parasite surface.
These fatty acids are generated by variant FAD2 hydroxylases that principally use oleic acid (18 1Δ9) bound to phosphatidylcholine as a substrate.
Some carbon dioxide binds to blood proteins, principally hemoglobin, to form a compound known as carbamate.
