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Principal weaknesses of the study included lack of sensitivity analysis, exclusion of more severe leg ulcers, and characteristics of the study populations, making comparison with other districts within the UK or other countries difficult.
Its principal weaknesses are item redundancy and pattern response within select conceptual domains, which can be addressed by removing select items within each of the nine conceptual domains and also possibly by mixing items from different conceptual domains.
The small sample size and single locality of this study are its principal weaknesses.
The principal weakness of the method is that it currently does not allow efficient detection of single-base indels in homopolymers.
The principal weakness of the psychological autopsy design is recall bias.
The principal weakness of the study is the historical nature of the comparison.
The principal weakness of Isomap is the algorithm instability encountered in embedding of manifolds with local nonlinearity or discontinuity (Balasubramanian and Schwartz 2002).
Indeed, the fine reception afforded to the speech in the hall was, in a sense, its principal weakness.
Had Froome, inadvertently or otherwise, exposed Wiggins' principal weakness when required to accelerate suddenly during a long climb?
The social agenda, supposedly the greatest strength of the Workers Partyy, has proved to be its principal weakness.
The predominant response has been denial, with the Republican party degenerating into a squabbling apocalyptic cult and Obama's principal weakness seeming to be his palpable sanity.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com