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It crosses without hindrance the blood-brain and placental barriers to reach its principal target tissue, the brain.
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The model includes descriptions of the three principal target tissues for cancer identified in animal bioassays: liver, lung, and kidney.
Myostatin is a member of the transforming growth factor-β (TGF-β) family of secreted proteins that is almost exclusively expressed by skeletal muscle, and this tissue is also its principal target, where it inhibits myocyte hypertrophy (24, 27).
The Zymbal gland, a sebaceous tissue associated with the ear duct of certain rodent species, is a principal target for carcinogenesis by benzene.
IL-18 is increased in the systemic circulation of autoimmune diseases such as RA and Crohn's disease, in which the principal site of production of this cytokine has been demonstrated to reside in the inflamed target tissue [ 13, 29, 39, 40].
"The principal target is London," Bruguière declared.
Michael Essien was the principal target.
Researchers have discovered that an impressive raft of metabolic and reproductive hormones will activate bone tissue, often at doses much smaller than what is required to arouse the breast, gonads or other organs presumed to be a hormone's principal target.
The principal target of Monday's sanctions was Rosneft.
Councils, without a strategic housing plan, were the principal target.
In this case, the target tissue is myelin, a fatty substance that coats nerve fibers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com