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His principal study in philosophy is the Disputationes Metaphysicae (1597), which was used for more than a century as a textbook at most European universities, Catholic and Protestant alike.
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Many of the papers in our review may lie on the margins between pilot and proof-of-concept investigations and their emphasis on efficacy should perhaps be interpreted in this light, however none were described as proof-of- either concept or principal studies in their title [10 - 59], though one [ 42] was described as a phase II pilot study.
This human trial was part of the European Nutrigenomics Organization (NuGO) Proof of Principal Study (PPS) in which various omic techniques were applied [ 7], including transcriptomics, proteomics and metabolomics [ 8].
Phenotypic characteristics suggestive of Wolfram or Alström syndromes were evaluated by the attending diabetologist and verified by members of the research team within the principal study centre in Lodz.
The principal study outcome was in-hospital mortality.
The outcome is based on prevalence in 79 (68.1%) principal studies, mortality in 28 (24.1%) and incidence in 10 (8.6%).
CJ principal study design, participated in the design of the paper and finalization.
NK and HJGB conceived the principal study and participated in its design and coordination and helped to draft the manuscript.
The outcome is based on prevalence in 78 (89.7%) of the principal studies, mortality in six (6.9%) and incidence in three (3.4%).
In an earlier proof-of-principal study conducted in only two healthy mice, Yang et al. demonstrated the technical possibility of measuring murine LVEF with cardiac-gated FDG-PET [11].
The advantages of IHC, which include preserved tissue morphology, quick turnaround time and ability to assay small amounts of tissue such as core biopsies, have established it as the principal ancillary study in diagnostic pathology.
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CEO of Professional Science Editing for Scientists @ prosciediting.com