Sentence examples for principal signalling pathway from inspiring English sources

It therefore appears that VEGFR2 is the principal signalling pathway for VEGF-A and VEGF-C-mediated increased permeability.

Considerable effort has been directed towards understanding the molecular mechanisms of the involution process and this has resulted in the identification of the principal signalling pathways involved.

That receptor utilizes a G protein-coupled mechanism for cAMP generation as a principal signaling pathway in the thyroid [39].

Initiation of the principal signaling pathway of MHC class II molecules in human B lymphocytes requires the HLA-DRβ cytoplasmic tail [13].

The trend of radiation therapy improvements has been focused on tyrosine kinase cascade, the principal signaling pathway to development of new target molecules whose members play a pivotal role on cellular proliferation as migration and tumor invasiveness mediators.

It is well known that apoptosis can be triggered via two principal signaling pathways: the death receptor-mediated extrinsic apoptotic pathway, and the mitochondrion-mediated (cytochrome c, caspase-9) intrinsic apoptotic pathway [9].

Apoptosis is triggered via two principal signaling pathways [12].

These anticancer agents are able to inhibit cell growth by acting on two principal signaling pathways of apoptosis.

However, to effectively inhibit pathways proximal to the principal signaling pathways used, it is necessary to better understand the molecular mechanism involved in resistance.

Collectively, these results indicate that the downregulation of IGF-IR/PI3K/Akt by luteolin is one of the principal signaling pathways for the induction of cell cycle arrest and apoptosis in HT-29 cells.

Since 2005, the US Food and Drug Administration FDAA) has approved six new target agents for metastatic RCC that antagonize two principal signaling pathways: the vascular endothelial growth factor receptor (VEGF) and the mammalian target of rapamycin (mTOR).