While these data provide principal proof-of-concept that statins may present a promising adjuvant strategy in patients undergoing mechanical ventilation, their translation into clinical practice requires careful consideration.
When she came to Atlanta in 1999, she wrestled with a dysfunctional board, closed more than 20 schools and replaced 90 percent of the principals — proof, she said, that she is not afraid to clean house.
This work demonstrates the successful application of macroarray methodology using randomly primed and sequence-nonspecific amplified cDNAs derived from grapevine total RNA extracts, and provides a proof-of-principal for unbiased multiplex detection using a single robust platform.
A proof-of-principal experiment to investigate the interaction of a proton beam, high magnetic field, and high-Z target is planned to take place at CERN in early 2007.
These results are a proof-of-principal that large fusion proteins (> 10 kDa) can be assembled by diblock ELPs without the need for bioconjugate chemistry, which greatly simplifies the design and evaluation of targeted drug carriers.
In an earlier proof-of-principal study conducted in only two healthy mice, Yang et al. demonstrated the technical possibility of measuring murine LVEF with cardiac-gated FDG-PET [11].
Moreover, we demonstrate in a proof-of-principal study that CD4+ Tregs can be engineered with class I-specific TCRs capable of suppressing immunity in vivo.
The findings reported here are proof-of-principal for value of sequential multiplex PCR capsular serotyping for determination of regional serotype distribution and specifically among cases of pneumococcal meningitis.
Nonetheless, the anti-tumor effects of PTH provide proof-of-principal for the use of bone-anabolic agents against myeloma bone disease and osteolytic breast metastases.
Thus, the approach established and described in this study provides proof-of-principal that it is effective and valuable in elucidating the functional contributions of miRNAs.
