The government had two principal problems: to make peace and to restore peacetime finance.
Among these constraints, voltage regulation is one of the principal problems to be addressed in distributed generation.
The principal problem related to the use of native MSCs for transplantation is heterogeneous composition of cell population, including differentiated and undifferentiated cells.
The principal problem appears to be a failure of enforcement.
In the sterile-insect release technique, the principal problem is to develop compounds and methods for their application that would not result in introducing harmful residues into the environment.
Whereas there should be no principal (technical) problem to make use of an Adobe Flash Player also on Apple's mobile devices (iPhone, iPad and iPod touch), Apple has decided not to support Flash on these devices and therefore, applications such as FlaME cannot be used on them.
Consequently, the principal problem is reduced to estimating two kinds of parameters, namely U i,j ui,j) and Q i,j)(θi,j).
A principal problem, however, is to obtain experimental data for each of these candidates, such as the full-length RNA sequence and its function.
The comic characters Mr. De Niro has been playing in the last few years, like Louis and the smiler-with-a-knife political consultant of "Wag the Dog" (1997), represent, I think, an ingenious solution to his principal problem as an actor: how to use his enormous reserves of power without becoming predictably, formulaically "powerful".
Dr. McAllister said that in Dr. Taylor's case "the principal problem in escalating it to humans is one of scale, not of cell biology, and that is an easier problem to solve potentially".
