Sentence examples for principal pathways that from inspiring English sources

IFN-induced signal transduction, cytoskeleton remodeling, vesicle transport and proteolysis were the principal pathways that changed in infected MDCK cells.

Alternatively, by identifying the principal pathways that are the recipients of genetic susceptibility then there is scope for exploiting these insights for new treatment development.

Provided that one has sufficient knowledge of the amino acid biosynthetic pathways, and other principal pathways, that are active in heterocysts, the metabolism of heterocyst-containing filamentous cyanobacteria can also potentially be studied by metabolic flux analysis by using the ability of A. variabilis to assimilate fructose [ 32, 33].

A principal pathway that signals via mTOR is the PI3K/Akt signaling pathway, which is critically involved in the regulation of cell proliferation and survival.

Our data combined with those reported in the factor-B-deficient MRL mouse, however, strongly support the hypothesis that the principal pathway that drives complement-dependent renal injury in the MRL mouse is the alternative pathway.

Despite the current use of ET receptor antagonists and drugs targeting the two other principal pathways- that of NO with PDE5 inhibitors and that involving prostacyclin (PGI2) – meta-analysis of PAH trials shows existing therapies only moderately increased the most widely used objective evaluation of functional exercise capacity (6 min walk distance) by 11%.

The principal component of pathways that promote anti-apoptotic effects is Akt (Figure 2), which inactivates caspases, the major mediators of apoptosis, mitochondrial dysfunction, and subsequent release of cytochrome C [15].

The principal component of pathways that promote anti-apoptotic effects is Akt, which inactivates caspases, the major mediators of apoptosis, mitochondrial dysfunction, and subsequent release of cytochrome C [ 15].

Pathway completeness scores for all MetaCyc [47] pathways found in at least one community (or reference genome) were first subjected to principal component analysis (PCA) to identify pathways that contribute most to variability across the genomes/metagenomes (Figure S3).

Physical activity is a default condition for most mammals [5] and the regulatory pathways that control ATP production have evolved with exercise as a principal selection pressure [6] [8].

As a principal feature of breast cancer is uncontrolled proliferation, identifying and understanding the regulatory molecules and pathways that govern these cells is essential.