Sentence examples for principal pathways involved from inspiring English sources

These findings are complemented by biological assays for apoptosis, cell cycle progression and migration that support the data obtained from microarray analysis, and suggest that the multi-functional molecule UCH L1 plays a role in regulating principal pathways involved in oncogenesis.

The principal pathways involved in both, CO and RASopathies, are displayed on the PPIN, and also marked in the Figure  4 to facilitate the comparison.

One of the principal pathways involved in alteration of migratory activities is PI3K/Akt signaling pathway that has been implicated in driving metastatic phenotype in thyroid [ 104], breast [ 105], and other cancers [ 106], and PI3K activity is further increased by radiotherapy in certain tumors [ 107, 108].

It is well known that RAD51-dependent recombination is the principal pathway involved in the repair of replication-associated DSBs [ 42] and that WS cells show up-regulation of RAD51 foci and enhanced engagement of recombination after replication arrest [ 21, 22].

Considerable effort has been directed towards understanding the molecular mechanisms of the involution process and this has resulted in the identification of the principal signalling pathways involved.

Two principal pathways are involved in apoptosis: a pathway that is directly activated by death receptors and a pathway that involves mitochondria.

The principal advantage of using miRNA as therapeutics agents is that they could target several genes of redundant pathways involved in cancer development [ 87].

The principal chemical formation pathways involving gas phase reactions, as well as formation by catalytic reactions on grain surfaces or through dust fragmentation, are identified for both dense clouds and cometary comae.

Since caspase-3 can be activated by both principal apoptosis signalling pathways involving the initiator caspase-8 or -9, respectively, we next analysed the functional contribution of these distinct apoptosis pathways.

The researchers concluded that the neurological pathways involved in pleasure might also be involved in absence of pain.

Scientists have long known that the biochemical pathways involved in disease are complex, with numerous alternate routes.