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In fact: 1) the principal functional category involved in the EMT process concerns morphogenesis and development; 2) the most up-regulated genes belong to this category; and, finally, 3) some intracellular pathways are involved, whose engagement during kidney development and nephrogenesis is well known.
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This relationship follows the divide between the two principal functional categories of genes in the eukaryotic cell, the informational genes that are, almost invariably, most closely related to archaeal homologs, and the operational genes that are of bacterial provenance [ 66- 68].
The principal functional classes observed in the biological function category belonged to metabolic process (272), translation (271), protein metabolic process (204) and transport (175).
A brief overview of the principal functional groups is presented here.
Moreover, each functional category included many functional surface proteins.
Both of these represent highly significant functional category enrichments.
A phylogenomic tree was constructed for every functional category.
The second largest group was the "other" functional category.
Of the N. crassa orphan genes, only 6.1% have assigned functional categories, and no functional category showed enrichment.
We used the 11 major categories from the top level MIPS functional category annotation.
The "Cellular Processes" functional category represented the category with most genes impacted by Hfq (∼63%).
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CEO of Professional Science Editing for Scientists @ prosciediting.com