In mammals, IFN-γ, together with LPS, are principal inducers for expression of CXCL9, -10 and -11 in neutrophils, thereby mediating T-lymphocyte recruitment via the CXCR3 (for review [57]).
On the other hand, cessation of Rnase10 expression is a clear indication of direct androgen dependence of gene expression in principal cells, whose continued presence in ProxE-ARKO epididymis is signified by unaltered expression of principal cell-specific Ros1.
Architecture has never been the principal medium for the expression of the Chinese artistic impulse; for centuries conservatism and respect for tradition were paramount and stylistic innovation practically unknown.
If the novel photoreceptor CREs identified here represent the principal regulatory regions controlling expression of the genes in question, then one might expect there to be a correlation between the expression strength of a given CRE and the corresponding gene's transcript levels in vivo.
Peroxisome proliferator activated receptor alpha (PPAR α) is the principal regulator of the expression of fatty acid β-oxidation FAO enzymes and transporters [ 28].
The second problem is that measuring the principal components requires measuring expression of all the genes and this may not be desirable for clinical application.
The differentiation of mesenchymal cells into chondroblasts is regulated by the activity of the Sox9 transcription factor, which controls the expression of principal genes encoding the extracellular matrix proteins of cartilage, such as collagen type II and aggrecan [ 4].
This observation supports the idea that neuropathologic processes related to AD and especially Aβ accumulation may induce deleterious effects on the expression of principal actors of the sphingosine 1-phosphate metabolism.
