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For me, the principal drawback is the growing gap between my age and that of the students, something well known to every teacher.
The principal drawback is that no inference to the underlying target population is possible.
The principal drawback is the lasting presence of the transposase, which could remobilize the transgene once it has been inserted.
These advantages include high selectivity and benign environmental impact; however, a principal drawback is low yield and/or productivity, which limits economic viability.
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The principal drawback was soprano Barbara Frittoli, her voice too small and her tone too shrill for comfort.
The chariot's principal drawbacks were its expense and unsuitability for difficult terrain.
However, the principal drawbacks are that electron-beam modification occurs under ultra-high vacuum conditions, limiting the potential of this technique for multicomponent biomolecule nanopatterning.
The principal drawback, however, is Wolfgang Koch's curiously bland Sachs.
Mr Jensen argues that their biggest drawback is what economists call the principal-agent problem: the split between the people who own the company (principals) and those who run it (agents).
The principal component might be a good alternative method but its drawback is that it may fail when the distribution has multi-modal.
One drawback is rough water.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com