Sentence examples for principal downstream effector from inspiring English sources
BRAF is the principal downstream effector of KRAS [17], [18] and its oncogenic V600E mutation is mutually exclusive with KRAS mutations in CRCs [19].
It is worth noting that cytoplasmic accumulation of β-catenin (the principal downstream effector of Wnt canonical activation) was found to be independent of β-catenin mutations in the subclass of more aggressive tumours (Hoshida et al, 2009).
KRAS (V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) mutations are the major determinant of response to anti-EGFR antibody therapy; however, in the population of cancer patients with wild-type KRAS tumors, other mutations have a significant role, including the Val600Phe mutation in BRAF, a principal downstream effector of KRAS.
Two principal downstream effectors are responsible for relaying mTOR signaling: the translational repressor protein eukaryotic initiation factor 4E (eIF-4E) binding protein 1 (4EBP1) and the ribosomal protein S6 kinase 1 (S6K1) [ 6].
ROCK is one of the main RhoA downstream effectors.
E-Cadherin/catenin signaling has long been known a downstream effector of EGFR signaling [15 18].
The downstream effector of PHD1KDM5B is therefore required for the KDM5B-induced demethylation of H3K4me2/3.
Inhibition of the downstream effector Gli has also received much attention.
The same effect was obtained by blocking the common downstream effector Akt.
dHand cannot be directly regulated by Isl-1, but can be regulated by BOP, a downstream effector of MEF2c.
TCTP cannot affect downstream effector cells until it is secreted.
