Sentence examples for principal difficulty that from inspiring English sources

The principal difficulty that hinders modeling effort is the absence of the measured values of kinetic constants of many biochemical reactions forming the CS.

The principal difficulty that I have as a clinician with the epidemiological data presented by Rachet et al in this issue, pp S116 S118 is the grouping of all types of leukaemia together.

The principal difficulty is that there is either no meaningful measure of the output of a public service defense, for example—or output is complicated and multidimensional as with education or health.

The principal difficulty was that, for many problems, the number of possible paths through the "maze" was simply astronomical (a situation known as a "combinatorial explosion").

The principal difficulty observed was that after about 10 hours of use (an average of 420 trials), children tended to become bored with the software.

The principal difficulty at present is that there are no official rules.

The principal difficulty in this process is that large land areas are required, and energy is needed for pumping the water.

I had not dreamed up the idea that my principal difficulty with Murdoch was my refusal to turn the paper into an organ of Thatcherism.

A review of PF pesticide model applications reveals that the principal difficulty of their application is still the appropriate parameterization of PF and pesticide processes.

The principal difficulty with this approach is that it is highly dependent on the model equations.

The onus for proving that courses are worthy will now lie with principals and guidance counselors, underscoring the difficulty that the association had encountered in positioning itself as an arbiter of academic excellence.