Sentence examples for principal difficulty is from inspiring English sources

The principal difficulty is that there is either no meaningful measure of the output of a public service defense, for example—or output is complicated and multidimensional as with education or health.

The principal difficulty is the large number of interactions between electrons that must be taken into account; this fact makes computational quantum chemists some of the most demanding users of computers and, increasingly, of supercomputers.

A principal difficulty is to obtain an efficient pentose uptake in the presence of high glucose and inhibitor concentrations.

The principal difficulty was that, for many problems, the number of possible paths through the "maze" was simply astronomical (a situation known as a "combinatorial explosion").

- As for the higher level of chromatin packaging, the existing experimental data are so controversial that no comprehensive picture can be drawn., The principal difficulty was the absence of an experimental tool allowing for the study of the DNA path in chromatin within an undisturbed cell nucleus.

The principal difficulties are the following: (1) Diffusion to the electrodes and reaction there must be sufficiently rapid to make bulk back reactions unimportant.

Different methods have been developed to detect and quantify NO, where one of the principal difficulties are the accurately detection in cellular system with low levels of NO production.

The principal difficulties were linked to the obtaining of bottles and caps for the ABHR bottling.

The principal difficulties are in the east around the town of Abeche and near the border with Sudan.

The importance of liquid helium temperature cooling technology in the aerospace field is discussed, and the results indicate that improving the efficiency of liquid helium cooling technologies, especially the liquid helium high frequency pulse tube cryocoolers, is the principal difficulty to be solved.

My principal difficulty, though, was the casting of Stephen Fry as the meant-to-be endearingly eccentric art professor and museum curator.