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In two consecutive prior studies of younger African American smokers with considerably less total cumulative tobacco smoke exposure, we demonstrated that the principal changes of the DNA methylation signature in response to smoking were in the xenobiotic response pathway regulated by the AHRR gene [ 11].
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One of the principal changes is the use of a larger volume of blood (5 mL) in order to increase sensitivity.
Principal changes were a) increase of absolute monocyte counts; b) selective defect of TNFα and IFNγ production from PBMCs after stimulation with S.pneumoniae; and c) increase of absolute counts of Tregs mainly observed among patients with H1N1-related pneumonia.
In the beginning, he said, there were, "a significant number of principal changes.
In its reported structure, at a relatively high resolution (1.63 Å); the principal changes are vertical displacements of helices F and G without significant tilts or rotation (Fig. 8O) [39].
Numerous helper functions enable comparative analysis of experimental and theoretical data, and visualization of the principal changes in conformations that are accessible in different functional states.
One of the principal changes asked those receiving notifications to sign a pledge not to make unauthorized disclosures.
The principal changes in the chemical composition of the water results from halite dissolution, silicate weathering, as well as ion exchange and pyrite oxidation.
The hippocampus showed regional structural volume reduction in CCHS subjects, with the principal changes occurring in the rostral portion of the left hippocampus.
The principal change involved the replacement of Mr. Silverman's hand-picked top lieutenant, Teri Weinberg, with a veteran NBC program development executive, Angela Bromstad.
The principal change in the DLS profile of serum after the addition of NP+ (cationic), NP– (anionic), and TEG (neutral oligo ethylene glycol -capped particles) was the shift of the ∼9 nm hydrodynamic diameter (dh) peak to ∼20 nm, evidencinglycol -cappedn of discrete particlesP complexes, namely, the protein corona.
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