Sentence examples for principal challenge with from inspiring English sources

The principal challenge with building an accurate surface model is that the sedimentary rock mass is coarsely sampled by drilling exploration holes which are typically a long distance apart.

The principal challenge with this technique was to obtain a significant quantity of RNA from SOPs and to ensure that the integrity of the RNA after laser microdissection was sufficient for subsequent gene expression analysis such as quantitative real time PCR and microarrays.

A principal challenge in dealing with the origin of eukaryotic cells is to understand the origin of eukaryotic cell structures and eukaryote-specific cellular processes in the onset of the appearance of the last eukaryotic common ancestor (LECA).

The principal challenge, he said, will be to balance people's memories with the demands of the stage.

The principal challenge would be evacuating large numbers of people from a small island with limited scope for transportation and other logistic action, especially if the local airfield was affected by ash.

The principal challenge is how to alert the pilots to their situation without overloading them with information, especially in a crisis when they become highly focused.

He went on to study Russian language and area studies at the Russian Institute at Columbia University, and became convinced that the principal challenge of American diplomacy in the post World War II period would be dealing with the Soviet Union.

The principal challenge now is delivery, not further policy refinement".

For the restaurant operator the principal challenge is to blend in and not overwhelm a museum's distinctive look and style with a design that clashes or contradicts.

The principal challenge for experienced users of Windows is the total absence of a Start button, familiar since 1995 as the place with all their programs and shortcuts stored in a huge list.

The principal challenge for Fregeanism is the challenge of giving a non-metaphorical explanation of the nature of sense.