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The rise is deeply troubling because it was seen in San Francisco, one of the principal centers of the AIDS epidemic that was first detected in 1981.
The road leads up a hill to the Afghan Counterinsurgency Academy, one of the principal centers for teaching tactics to Afghan officers and enlisted men.
On May 26 , 1994 he and his wife, Natalia, flew from their home in Vermont to Magadan, on the Sea of Okhotsk, which had been one of the principal centers of the gulag system.
"The bank and Rom Whitaker have been one of the principal centers of crocodile research and conservation-related activities in India," said Dr. John Thorbjarnarson, a conservation zoologist with the Wildlife Conservation Society, which is based at the Bronx Zoo.
"With this collection, the Minneapolis Institute of Arts will become one of the principal centers for the study, display, and research of Japanese art in this country," said Kaywin Feldman, the director and president.
Rising from the ashes, Chicago entered the Gilded Age as one of America's principal centers of commerce, industry, and culture.
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It is quite extraordinary that the principal center for euro-denominated financial transactions is outside the eurozone.
During the previous six months, the Lal Masjid had become the principal center of radical Islamist resistance to Musharraf's rule.
What followed, especially in Punjab, the principal center of the violence, was one of the great human tragedies of the twentieth century.
Largely because of Louis Kahn, who went there to teach in the late forties, the Yale Department of Architecture had become the principal center of new architectural ideas.
He said it was an opportunity for New York City to become the principal center for the $260 billion global market for medical devices and diagnostics.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com