Sentence examples for principal cellular target from inspiring English sources

In these experiments, AICA was completely protective, establishing GARFTase as the principal cellular target.

Consequently, as osteoblasts are the principal cellular target of PTH, intermittent administration of PTH may be useful as a pharmacological stimulator of new bone formation during distraction osteogenesis.

Principal cellular targets include endothelial cells with increased chemokine production and macrophages with increased chemokine and cytokine production.

The principal cellular targets and biologic effects include activation of endothelial cells, neutrophil activation, fever, liver synthesis of acute phase proteins, muscle and fat catabolism, and apoptosis of many cell types.

Smooth muscle and fibroblast cells are principal cellular targets of progerin nuclear accumulation in vivo, in both HGPS and elderly populations (McClintock et al., 2006; McClintock et al., 2007; Olive et al., 2010).

Importantly, the sensitivity of rabbit PMNs to the leukolytic activity of PVL mirrors that of human PMNs [17], making the rabbit an excellent model species because PMNs are a primary cellular target of PVL and the principal component of host innate immune defense.

The mRGCs in this design serve as the principal site of signal integration and therefore, have now emerged as a unique cellular target for therapeutic intervention in circadian clock related disorders.

DNA is the most important cellular target for the lethal effects of ionising radiation, with double-strand breaks (DSBs) proposed to be the principal lesions responsible for radiogenic cell killing (Ward, 1988; Iliakis, 1991).

cruzi co-infection in their common cellular target: human macrophages.

However no cellular target has been identified so far.

DNA represents a third cellular target of.OH.