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Nutrient deficient soils may be the principal causative factor in the devastating endemic osteoarthritic disease that afflicts two-thirds of the women in Maputaland, for instance.
Mutations of the MECP2 gene were later identified as the principal causative factor for Rett syndrome, a severe progressive neurological disorder affecting almost exclusively females [ 2].
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The bacteria Bartonella henselae has been known as the principal causative agent of cat-scratch disease (CSD) since 1992.
Streptococcus pneumoniae (S. pneumoniae) is the principal causative agent of CAP requiring hospital or ICU admission [ 8].
In disease biology, the importance of TEs is highlighted by the potential association with genetic instability, one of the principal hallmarks and causative factors in cancer [ 12- 15].
In disease biology, the importance of Alu elements is further highlighted by the potential association with genetic instability, one of the principal hallmarks and causative factors in cancer [ 15, 16].
Mr. Barton said tests with cells in the laboratory suggested that blue light might be a "causative factor" in macular degeneration, the leading cause of blindness in older Americans.
The principal message of the article is very simple: TEs might not be a causative factor in speciation.
I have concluded that it is innate motivation that is the causative factor.
"I'm not saying Islamophobia is the only causative factor, but surely it plays a part," she says.
However, infrequently epistaxis is the causative factor.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com