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When analysing smaller subgroups subsequent to the principal analysis the chance of spurious findings may increase.
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The principal analysis of the primary outcome will employ the intention-to-treat (ITT) approach.
The principal analysis of the study endpoints will employ the intention-to-treat (ITT) approach.
As expected, mean values of time to PC90 based on observed timepoints were higher than in the principal analysis using the model-based approach (Table 2).
KBL conceived and designed the study, conducted the principal analysis, and drafted the manuscript.
PPSS conducted the principal analysis and revised the manuscript.
J-LV, JO, BLT, RG, and DPS conducted the principal analysis and drafted the manuscript.
The principal analysis consisted of the patient distribution according to HCV genotype and liver fibrosis stage.
The principal analysis was defined as the main analysis performed on the primary outcome.
The principal analysis then involved comparing the frequency of precursor signs of infection in the two groups.
Patients excluded from the principal analysis were included in the sensitivity analysis.
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