Exact(4)
VE-cadherin, a principal adhesion molecule in the endothelium, can be ubiquitinated by the MARCH family Ub E3 ligase K5 (Mansouri et al., 2008).
As a principal adhesion molecule, cadherins are under constant regulation in order to maintain a balance between stability and plasticity of the cellular barrier (Cadwell et al., 2016; Aparicio et al., 2012).
Consistent with this hypothesis, we demonstrated that the CD11b complement receptor type 3, the principal adhesion receptor on leukocytes for Candida albicans [32] is strongly decreased in macrophages from mice under HF diet, suggesting a default of pathogen-opsonised recognition in this dyslipidemic context.
Previous works reported that in this model of autoimmune nephritis, VLA-4/VCAM-1 is the principal adhesion pathway for circulating leukocytes extravasation into renal interstitium [ 8].
Similar(56)
The principal families of adhesion molecules involved are the selectins, the integrins, the cadherins, and variants of the immunoglobulin supergene family.
CD62P (P-selectin) is up-regulated on retinal venules, the principal sites of leukocyte adhesion and diapedesis in EAU, at the time of blood-retina barrier breakdown and leukocyte infiltration of the retina.
Monoclonal antibody or peptide therapies could, however, provide proof of principal to determine whether adhesion-reversal is of clinical benefit, and might be used in intensive care facilities in more affluent countries.
E-cadherin, found at adherens junctions, is the principal effector of cell-cell adhesion [ 40].
Furthermore, the dengue virus E protein is a potential target of inhibition due to its principal role in cell membrane adhesion [ 39].
Claudins are the principal molecules that regulate cell-cell adhesion at tight junctions and are expressed at very low levels in men with low testosterone levels.
Abrasion and adhesion are observed to be the principal wear mechanism from images of tool tip.
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