Sentence examples for principal activators of from inspiring English sources

Toll-like receptors (TLRs) are the principal activators of the innate immune response.

Together, these studies support a role for NAC TFs as principal activators of SCW formation in fibres and vessels, acting in distinct combinations in each case.

Because DCs are potent APCs that function as principal activators of T cells, CCL19's capacity to facilitate the colocalisation of both DC and T cells may reverse tumour-mediated immune suppression and orchestrate effective cell-mediated immune responses.

The principal activators of Stat6 are IL-4 and IL-13, whose binding to cognate receptor complexes leads to recruitment of JAKs and JAK-mediated Stat6 phosphorylation, whereupon Stat6 dimerizes, moves to the nucleus and binds to specific promoter elements [ 60, 61].

Over years, free ferrous iron was proposed to be the principal activator of artemisinin [6, 8, 26, 29].

Indeed, TF is the principal activator of the extrinsic coagulation pathway, and as such is responsible for an intravascular procoagulant state.

The TF pathway, also referred to as the extrinsic clotting cascade, is the principal activator of clotting in the presence of systemic inflammation and generalized infection.

Among hubs, thrombospondin 1 (theS1) – the principal activator of the TGFβ1 peptide [ 14] – emerges because it links a wide range of matrix proteins mediating their interaction with cell-surface receptors.

The principal activity of PTEN is to dephosphorylate phosphatidylinositol 3,4,5-triphosphate (PIP3), produced by PI3K and a major activator of the cell survival kinase Akt.

The effects of ERK phosphorylation on the conformational manifold are opposite of the principal activator, CaM.

Conversely, in SARA ATRP, Cu0 plays the role of a supplemental activator as well as a reducing agent for the conversion of Cu II) to Cu(I), which is the principal activator.