Sentence examples for principal abnormalities in from inspiring English sources

The principal abnormalities in type 2 diabetes are impaired peripheral insulin action (insulin resistance), insulin secretory dysfunction, and glucagon hypersecretion further promoting hepatic glucose production.

The principal abnormalities in these mice include severe insulin resistance and hyperinsulinemia on a background of mild dysglycemia (approximately 20% elevated blood glucose compared to controls).

Growing evidence exists that immune mechanisms rather than direct viral cytopathology are responsible for the changes in vascular permeability, the principal abnormality, in both HFRS and HCPS [ 6, 15].

The main abnormality in diabetes is an excessively high level of blood sugar, or glucose.

Phosphate retention occurs early in the course of renal failure and there are data in favor of the hypothesis that this is the principal abnormality of SHPT [ 4].

In other disorders such as Parkinson's disease, CMT2A, and DOA, the principal abnormality is not at the mitochondrion, but within the mitochondrial cell signaling interface that maintains fitness of the mitochondrial pool.

The principal abnormality was extensive tubular intra-luminal erythrocyte cast formation associated with acute tubular necrosis (Fig.  1).

Later on, the lack of habituation was thought to be the principal interictal abnormality in sensory processing in migraineurs, hypothesized due to hypofunction of 5-HT pathway to the thalamus and cortex [58 62].