It is well known that caspase-3 has a primordial role in triggering the cascade of events that lead to apoptosis [ 2, 32, 37].
In mammals, the sexual fate is determined by a Y-linked Sry gene, which initiates a cascade of events to trigger the primordial gonads to differentiate into testes [ 4].
The few therapy-surviving cancer cells are surrounded by massive cell death triggering a primordial adaptive and reparative general wound healing response.
The fact that the universe has been around 13.8 billion years shows that primordial black holes will not trigger such a collapse, he says.
However, the risk of ovarian damage and infertility is present, particularly reduction of the primordial follicle reserve, which may trigger POF (premature ovarian failure) [ 4, 5].
It was achieved by first inducing the skin cells into embryonic-like stem cells and then switching on a key gene called Sox17 to trigger their conversion to primordial germ cells, Professor Surani said.
A sustained, lasting over hours, Ca2+ increase, which is primordial for new gene expression, is triggered in T cells via the Ca2+/calcineurin/NFAT pathway [ 55].
We conclude that Tsc/mTORC1 signaling in oocytes plays an indispensable role in preserving the primordial follicles in their dormant state and in triggering the activation of selected primordial follicles.
And the primordial galaxies collided and merged to form bigger and bigger versions of themselves, in the process triggering more star formation and more supernovae.
It is possible that in humans too, even though some primordial follicles may survive chemotherapy exposure despite the presence of significant DSBs, their growth may be halted after ovulation triggers the resumption of cell cycle from prophase-I.
