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Simulating a reduced gravity environment experienced in spaceships in a laboratory setting for studying different technical aspects (fluid transfer or propellant behavior, for example) is a primordial step prior to extraterrestrial explorations.
As the LV ejection fraction is the strongest prognostic determinant in heart failure patients, while LV volume and mass are independent predictors of mortality and morbidity, a first primordial step in assessing DCM patients is the reliable quantification of the severity of chamber dilatation and dysfunction.
As illustrated above there is a strong support that the interaction between EOC and its surrounding microenvironment is a primordial step in the development and progression of metastatic EOC.
Considering ligand-receptor binding as a diffusion-limited reaction [ 9, 10], we investigated how receptor distribution may impact this primordial step of signalling, ligand binding to receptor extracellular domain.
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What a dumb system!" "Tell us again why you couldn't read Harry Potter books on e-readers?" "Grandpa, what do you mean 'monochrome'?" This week, though, e-book readers just took their first slimy steps out of the primordial soup.
The process of early gametogenesis requires a succession of coordinated steps, including primordial germ cell (PGC) specification, migration to and colonization of the gonadal ridges, proliferation, and differentiation into more mature gametes [1].
From there, it is but a small – though not necessarily easy, given that uniformitarianism is hardly applicable here, – step back to the primordial gene pool.
And even more intriguing is trying to understand the (very) first molecular steps leading to the primordial cells and their early evolution.
These early steps in the formation of primordial follicles are critical, since primordial follicles constitute the fundamental reproductive units of the ovary and give rise to all dominant follicles.
65 This finding, together with the finding that experiments simulating the early earth's atmosphere 32 yielded as many as 10 different natural amino acids still dominant in modern proteins, 34 lays the foundation for a theory that the genetic code evolved under primordial conditions 12, 26 in two main steps (early and late) of amino acid incorporation to primeval proteins.
Another is organ-follicle-culture system using a two-step strategy for oocyte development from primordial follicles.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com