This near-optimality could be the outcome of extensive early selection during the co-evolution of the code with the primordial, error-prone translation system, or a result of a unique, accidental event.
They show that the putative, primordial two-letter genetic codons encoding a 10 amino acid repertoire were nearly optimal in terms of error minimization, and conclude that that this robustness could be the outcome of extensive early selection during the co-evolution of the code with the primordial, error-prone translation system.
Its incarnation in the body is interpreted as a penalty incurred for some primordial sin or error.
Generally, the cause has been found in the supposition of some primordial ignorance or error rather than in a sinful act of disobedience or revolt i.e., in an intellectual rather than a moral defect.
As the mode sign estimation is sequential it is primordial to not commit an error at the beginning to avoid its propagation.
By measuring key cross sections, one can adjust η to reproduce the current measured values of primordial elemental abundances With present error bars, the D d,p T and D d,n 3He cross sections at energies in the range of a few hundred keV make large contributions to the uncertainties in deuterium abundances predicted by BBN network calculations (for η = 5.1 × 10-10.
One of the leading hypotheses is that the primordial code had to reduce errors in translation in order to provide for the efficient synthesis of functional proteins.
Combining quasar data with the photometric luminous red galaxy (LRG) sample of Ross et al. (2011) and Ho et al. (2012), and marginalizing over all bias and shot noise-like parameters, we obtain a constraint on local primordial
Apparently, to escape this error catastrophe [ 1], primordial life had no other means but to use the ribozymic precursors of the synthetases to aminoacylate tRNAs.
A common feature of the stereochemical theory and the coevolution theory that is central to the present study is that the level of error minimization in the primordial codes is assumed to be low but is thought to have increased to the present level as a results of late amino acid reassignments (stereochemical theory) or capture of new amino acids (coevolution theory).
