Sentence examples for primordial development from inspiring English sources

Precise synchronised signals are thought to mediate the initial stages of mammary primordial development, since early stages of mammary morphogenesis progress in a highly stereotypical manner [ 14].

Known key regulators of normal mammary primordial development, including Edar, Fgfr2, Gata3, Msx1, Msx2, Nrg3, Pthlh, and multiple Wnt signalling components were expressed specifically within the embryonic mammary epithelium when compared to the mesenchyme (Additional file 2) [ 15- 23].

As more genes and pathways are determined to regulate embryonic mammary primordial development, these networks can be extended and expanded which will permit assessment of potential genetic hierarchy and pathway convergence and aid experimental design to clarify these issues.

In particular, lack of Gata3, one of the most highly expressed genes expressed by the embryonic mammary epithelium in our analysis, leads to defective mammary primordial development at stages prior to E12.5 [ 21].

A recent study profiling genes expressed by micro-dissected E15.5 stage Pthlh-/ and wild-type mammary primordia, to study ductal morphogenesis, detected many changes in genes expression by the Pthlh mutant primordia, consistent with Pthlh signalling being a key component of mammary primordial development [ 50].

All these factors stimulate primordial follicle development except AMH that inhibits follicle development.

To understand the nature of primordial follicular development in adult life, we traced the in vivo development of labeled primordial follicles to different ages in the Sohlh1-CreER T2 R26R mice.

The systems biology approach taken with this network analysis of primordial follicle development identified clusters and modules of genes involved in this critical development process.

This sub-network also identified connective tissue growth factor (Ctgf) [16], [36] as a putative regulator of primordial follicle development.

Previously cell-to-cell communication with extra-cellular growth factors has been shown to regulate the initiation of primordial follicle development.

A systems biology approach was used to identify regulatory gene networks essential for primordial follicle development.