Thus, for complementary GCC and GGC triplets, the palindrome symmetry of the ancestral acceptor stem makes the primordial two classes of r-aaRSs, and their modes of recognition, functionally undistinguishable.
However, as the morphology of an atretic follicle is yet to be accurately established, we decided to instead reliably group follicles into four classes – primordial, primary, secondary and antral – depending on their morphology, and counted those follicles that contained a cross-section of the oocyte.
This particular function is ubiquitous across the jawed vertebrates and is likely the primordial function of the class I protein.
We believe that our results provide a relatively conclusive picture of how the two distinct classes of primordial follicles develop under normal physiological conditions.
Taken together, this study presents several lines of in vivo evidence that clarify the distinct developmental dynamics of two classes of primordial follicles under physiological conditions and provides a solid foundation for studying how primordial follicles develop in humans.
In this study, by generating the Foxl2-CreER T2 and Sohlh1-CreER T2 inducible mouse models, we have specifically labeled and traced the in vivo development of two classes of primordial follicles, the first wave of simultaneously activated follicles after birth and the primordial follicles that are gradually activated in adulthood.
We have also determined the age-dependent time periods required for the two classes of primordial follicles to develop into advanced stages and have shown that the developmental dynamics were completely different for the two types of primordial follicles (Table 1).
Perceptually, one may be a primordial emergence of form.
For oocyte quantification, every fifth section was scored for the presence of the following classes of oocytes: primordial, primary, secondary, pre-antral and antral, using the criteria previously described.
