Sentence examples for primitive compartment from inspiring English sources

The aberrant activation of this pathway in prostate tumors [23] and its enrichment in PSC is consistent with the notion that prostate cancer may arise in the primitive compartment.

The total number of active HSC in the most primitive compartment (N0) is ∼400 [4], whereas we have ∼3.5×1011 as the average daily output of the hematopoietic system [6].

The enrichment of several TF-binding motifs in genes that are overexpressed in the prostate stem cell niche supports the notion that this is a self-renewing primitive compartment (Table 3).

Activating mutations and overexpression of numerous components of the Wnt/β-catenin pathway are present in patients with advanced prostate tumors [74], indicating that these tumors may arise in the primitive compartment.

Within the human hematopoietic hierarchy, we previously demonstrated peak miR-126 expression and bioactivity within the CD34+CD38−CD90+ primitive compartment (Gentner et al., 2010).

Interestingly, no shift in the expression pattern of these genes into the anterior primitive myeloid compartment was detected, nor was a premature expression of hematopoietic genes in the posterior compartment.

This may indicate that leukaemia initiation typically occurs in a more primitive cellular compartment, with some less primitive cell types acquiring leukaemic activity with time.

Furthermore, in primary cells, 7/8 samples studied showed higher induction of γH2AX expression occurring in the primitive CD34+CD38- compartment compared to the more mature CD34+CD38+ cells (P = 0.035, Figure 3e).

The impact of 'background LAP' on the reliable detection of specific (AML) LAP+ events is considerable: up to 0.1% of WBC and up to 10% of primitive marker compartment is possible; as a result, specific detection of MRD <0.1% is compromised.

Several of the enriched promoter binding motifs are shared between the prostate epithelial/mesenchymal compartments and their epidermis/dermis counterparts, indicating their likely relevance in epithelial/mesenchymal signaling in primitive cellular compartments.

Although the stability of the hematopoietic system has long been recognized, it has become clear that plasticity of stem and progenitor cells allows the crucial regulation of primitive cell compartments during inflammation.