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Lower and higher priming activities were not as effective even though a statistically significant difference was seen between the 15 MBq and 2.5 + 12.5 MBq groups when the minimum tumor volume was reached (days 16 23).
Thus, inactivating UNC-13L decreased the priming activities of both UNC-13S and UNC-13L.
The priming activities of the UMB-click-xylosides 13a and 13b and the commercial xyloside were compared at various concentration (50 μM, 100 μM, 300 μM, 600 μM, and 1 mM).
Two identical replicase molecules are held together in a complex with the replicative helicase and subunits with priming activities, allowing two identical alpha catalytic subunits to assume different functions on the two strands of the replication fork [ 15].
Thus, CRT may be able to deliver the linked antigens to dendritic cells through their specific binding with CD91 to facilitate cross priming activities.
Similar(55)
The availability of this system should facilitate efforts to elucidate the viral and host requirements for HBV protein priming, and help characterize why HP expressed using this system has priming activity, while other systems that produce priming active DP are unable to produce priming active HP.
Mn2+ affects the function of DP by stimulating in vitro protein priming activity, allowing for low level Dε-independent protein priming and inducing an alternate DP conformation.
If an increase in the OTR is a measure of priming activity, the expectation is that compounds inducing defense priming would, while priming-negative compounds would not induce an increase in oxygen consumption.
HP expressed by in vitro translation in rabbit reticulocyte lysate does not show any priming activity even though the same translation system was the first used to produce a priming active DP.
Saturation was also avoided by giving the second administration no earlier than 24 h after the priming activity.
In the groups receiving a priming activity, the minimum relative tumor volumes were largest in the 0.5 + 14.5 MBq and 10 + 5 MBq groups but the mean values were generally smaller than if a single administration was given (15 and 30 MBq).
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