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Such primed states, in which multiple LSMGs are co-expressed, have been suggested as a characteristic feature of tissue-specific (haematopoietic) stem cells [50], [77], [78]; similarly, evidence that key genes may be primed for activation in ES cells has also been presented [15], [79].
In these regions, the mean shear stress is relatively low and the NF-κB pathway may be primed for activation.
Increasing evidence has suggested that QSCs are not in a dormant state but, rather, primed for activation and differentiation (Cheung et al., 2012; Crist et al., 2012).
Moreover, these observations indicate that specific cellular proteins and/or pathways must exist to facilitate H1 displacement from target gene regions primed for activation.
Microglia in the aged brain have been shown to be primed for activation, a state of exaggerated inflammatory reactivity and persistent neuroinflammation.
Importantly, H3K4me1 deposition has been shown to be triggered by lineage-specifying TFs [ 47], and not to change in response to stimulus [ 35, 89] (but see [ 48, 93]), and interpreted to mark enhancers "primed" for activation [ 97].
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These stored mRNA are primed for rapid activation and translation in the presence of nutrients.
Transient acetylation and deacetylation of these promoters may keep these promoters unexpressed but at the same time primed for future activation upon receiving the external stimuli.
Such clustering was observed at the TH2-cell locus with neighboring interleukin 4, 5, and 13 genes in type-2 helper T cells (TH2 cells) being primed for transcriptional activation (Cai et al. 2006).
In A. fumigatus however, most transcripts present at time 0 persisted in the conidium after one year of storage at room temperature; (iii) the third category of genes includes those that are primed for rapid activation and translation in the presence of nutrients.
Multiple studies have confirmed that human exudate neutrophils collected in skin windows are primed for enhanced metabolic activation and phagocytic activity [ 158, 159 , 160 161].
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